DNA repair gene status in oesophageal cancer
نویسندگان
چکیده
منابع مشابه
OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage
Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...
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X-ray repair cross complementing group 1 (XRCC1) encodes a protein involved in base excision repair. We examined the association of polymorphisms in XRCC1 (codon 194 Arg-->Trp and codon 399 Arg-->Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina. No association was observed between XRCC1 codon 194 genotype and breast cancer, and ...
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A new pathogenetic mechanism leading to cancer has been delineated in the past 3 years when human homologues of DNA mismatch repair (MMR) genes have been identified and shown to be involved in various types of cancer. Germline mutations of MMR genes cause susceptibility to a hereditary form of colon cancer, hereditary nonpolyposis colon cancer (HNPCC), which represents one of the most common sy...
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متن کاملGene specific DNA repair
There is increasing interest in gene-specific repair studies. This aspect of DNA repair is currently under intense investigation and new laboratories are entering the field. The data are coming in rapidly and we are in the midst of exciting developments. Accordingly, it is premature to build extensive models of the regulation and biological importance of gene specific repair. The purpose of thi...
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ژورنال
عنوان ژورنال: Molecular Pathology
سال: 1999
ISSN: 1366-8714
DOI: 10.1136/mp.52.3.125